The main purpose of this project is to find novel treatments for pulmonary hypertension. To achieve this, Karins group aims to:
Use synchrotron-based imaging combined with other methods to investigate the pathobiology of different subtypes of pulmonary hypertension with specific focus on how extracellular matrix components can regulate cell function and vascular remodeling, in humans and in animal models.
Investigate extracellular matrix turnover within diseased pulmonary vessels and proteolytic fragments in peripheral blood to screen for potential therapeutic targets and biomarkers for disease burden and treatment effects.
Evaluate animal models for similarities with human pulmonary hypertension using 3D imaging to enable time course experiments to decipher disease mechanisms.
Further investigate the role of intrapulmonary shunting between the pulmonary and bronchial circulation in the pathobiology of pulmonary hypertension.
Through collaborative projects Karin is also developing synchrotron-based methods for more efficient cardiac phenotyping of knockout mice and study other vascular remodeling processes like the postnatal physiological closure of the ductus arteriosus.
Read more about Karin Tran Lundmark in the Lund University Research Portal