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Karin Tran Lundmark receives Heart-Lung Foundation grant of 2.4 million SEK

Synchrotron-based imaging

Karin Tran Lundmark was awarded funding from the Heart-Lung Foundation for the project "Synchrotron-based imaging to decipher cardiovascular pathobiology". The funding includes 800.000 SEK per year for 3 years.

The main purpose of this project is to find novel treatments for pulmonary hypertension. To achieve this, Karins group aims to: 

  • Use synchrotron-based imaging combined with other methods to investigate the pathobiology of different subtypes of pulmonary hypertension with specific focus on how extracellular matrix components can regulate cell function and vascular remodeling, in humans and in animal models. 

  • Investigate extracellular matrix turnover within diseased pulmonary vessels and proteolytic fragments in peripheral blood to screen for potential therapeutic targets and biomarkers for disease burden and treatment effects. 

  • Evaluate animal models for similarities with human pulmonary hypertension using 3D imaging to enable time course experiments to decipher disease mechanisms.  

  • Further investigate the role of intrapulmonary shunting between the pulmonary and bronchial circulation in the pathobiology of pulmonary hypertension. 

  • Investigate the use of currently available therapies for pulmonary hypertension by registry- and survey-based studies. 

Through collaborative projects Karin is also developing synchrotron-based methods for more efficient cardiac phenotyping of knockout mice and study other vascular remodeling processes like the postnatal physiological closure of the ductus arteriosus. 

Read more about Karin Tran Lundmark in the Lund University Research Portal