Project #10

Autologous Bone Marrow Transplantation for treatment of Multiple Sclerosis - Endogenous Hematopoietic Stem Cell Activation?

Purpose | Our study seeks to contribute novel insights into the development of novel HSC-based regenerative strategies for multiple sclerosis (MS) using our recently defined connection point between peripheral and-CNS immunity. We aim to develop a better mechanistic understanding of this autologous cell therapy, keeping clinical translation in mind, thereby offering new hope for individuals affected by MS and potentially other autoimmune disorders.

Expected results | The data will help assess the safety and viability of aHSCT and endogenous HSC activation as potential treatments for MS. Findings will highlight opportunities to optimize these treatment strategies for better efficacy. The results will provide a solid foundation for further research into these and related therapeutic approaches.

Innovation | This project is novel as it combines HSC expertise and novel HSC transplantation approaches with a classic neuroinflammation disease, such as MS. A novel aspect is also that we will use this newly identified niche, to study interactions between immune stem cells and autoimmune cells.

Significance | Building on our interdisciplinary expertise, our project aims to make significant contributions to the understanding of cell transplantation as a treatment of MS. We plan to fill crucial knowledge gaps and advance new treatment protocols through autologous HSCT and endogenous HSC activation using read-outs in the newly identified vulnerable niche.  Success of this project will be a step towards enabling us to bring innovative cell-based therapies into routine clinical practice for those with MS.

Training & career development

The postdoc will be trained in the relevant techniques needed and will receive general training within the field of brain clearance and immunology. We take pride in advancing the career prospects of the postdoc. We offer a dynamic, creative and supportive environment. 

We aim to tailor the career development plan to the candidate's own wishes. There will be possibility to participate in the WCMM research school and other career development initiatives.

The candidate

We are looking for a motivated candidate to participate in cross-disciplinary research between the field of  multiple sclerosis, neuroscience and stem cell immunology. The candidate must be interested in working and training in both labs and must be flexible to do so. Good communication, an eagerness to learn, publication of several first author papers, experience with animal work and flow cytometry and knowledge of MS and EAE is preferred.

The candidate must hold a PhD degree. 

Main Principal Investigator

• Iben Lundgaard

Co-supervisor

• David Bryder