Lost by p129

The story

Loss of neuronal function and dopamine activity in Parkinson’s disease coincides with aggregation of phosphorylated alpha-synucein. The alpha-synuclein is phosphorylated at position 129, as visualized on the pipette. Dopamine activity is assessed by the loss of brown staining on brain cross-sections.

Research area

Neurological disorders, neurovascular disease mechanisms, pericytes, Parkinson’s disease.

Impact

We need to understand the underlying mechanisms of Parkinson’s disease better to be able to improve patient treatment. Raising awareness about Parkinson’s research to the public is key for a joint effort against disease related suffering.

Image description

This is a Tyrosine Hydroxylase-stained brain section (brown) with a pipette set to 129 in the background. The image is taken with a macro lens in the strong light of a cell lab hood.

Credits

To the scientist who left the Tyrosine Hydroxylase-slide in the lab.