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Dissertations and Publications

Dissertations/half time presentations:


Halftime seminar: Sabine Arve-Butler

“The role of neutrophils in Juvenile Arthritis and Systemic Lupus Erythematosus”

Supervisor: Robin Kahn

April 23rd 2020



February 2020

Steven J. Dupard, Ani Grigoryan, Stephanie Farhat, Daniel L. Coutu & Paul E. Bourgine. Development of Humanized Ossicles: Bridging the Hematopoietic Gap

Lotte Vanherle*, Hana Matuskova*, Nicholas Don-Doncow, Franziska E. Uhl and Anja Meissner. Improving cerebrovascular function to increase neuronal recovery in neurodegeneration associated to cardiovascular disease. Front. Cell Dev. Biol. Accepted (Jan 2020) doi: 10.3389/fcell.2020.00053


Linge P, Arve S, et al. NCF1-339 polymorphism is associated with altered formation of neutrophil extracellular traps, high serum interferon activity and antiphospholipid syndrome in systemic lupus erythematosus. Annals of the Rheumatic Diseases Published Online First: 08 November 2019. doi: 10.1136/annrheumdis-2019-215820

Wirestam L, Arve S, Linge P, Bengtsson AA. Neutrophils-Important Communicators in Systemic Lupus Erythematosus and Antiphospholipid Syndrome. Front Immunol. 2019;10:2734. Published 2019 Nov 22. doi:10.3389/fimmu.2019.02734

Gonçalves I, Singh P, Tengryd C, Cavalera M, Yao Mattisson I, Nitulescu M, Flor Persson A, Volkov P, Engström G, Orho-Melander M, Nilsson J, Edsfeldt A. sTRAIL-R2 (Soluble TNF [Tumor Necrosis Factor]-Related Apoptosis-Inducing Ligand Receptor 2) a Marker of Plaque Cell Apoptosis and Cardiovascular Events. Stroke. 2019 Jul 5: STROKEAHA119024379. doi: 10.1161/STROKEAHA.119.024379.

Lidington D*, Fares J*, Uhl FE, Dinh D, Kroetsch JT, Sauve M, Malik FA, Matthes F, Vanherle L, Momen A, Zhang H, Aschar-Sobbi R, Foltz WD, Macdonald RL, Husain M, Bear CE, Backx PH, Heximer SP, Meissner A* & Bolz StS*. CFTR therapeutics normalize cerebral perfusion deficits in mouse models of heart failure and subarachnoid hemorrhage. JACC Basic to Translational June 2019. 

Wigren M, Rattik S, Yao Mattisson I, Tomas L, Grönberg C, Söderberg I, Alm R, Sundius L, Ljungcrantz I, Björkbacka H, Fredrikson GN, Nilsson J. Lack of Ability to Present Antigens on Major Histocompatibility Complex Class II Molecules Aggravates Atherosclerosis in ApoE-/- Mice. Circulation. 2019 May 28;139(22): 2554-2566. doi: 10.1161/CIRCULATIONAHA.118.039288.

Waterton JC, Hines CDG, Hockings PD, Laitinen I, Ziemian S, Campbell S, Gottschalk M, Green C, Haase M, Hassemer K, Juretschke HP, Koehler S, Lloyd W, Luo Y,  Mahmutovic Persson I , O'Connor JPB, Olsson LE, Pindoria K, Schneider JE, Sourbron S, Steinmann D, Strobel K, Tadimalla S, Teh I, Veltien A, Zhang X, Schütz G; Repeatability and reproducibility of longitudinal relaxation rate in 12 small-animal MRI systems; Magnetic Resonance Imaging. 2019 Mar 12;59:121-129. doi: 10.1016

Anne Sofie Munk*, Wei Wang*, Nicholas B. Bèchet, Anne X. Cheng, Björn Sigurdsson, Abdellatif Benraiss, Maarja A. Mäe, Benjamin T. Kress, Douglas H. Kelley, Christer Betsholtz, Kjeld Møllgård, Anja Meissner, Maiken Nedergaard, and Iben Lundgaard. PDGF b is required for development of the glymphatic system. Cell Reports 2019 March 12; 26 (11).

Fábio F. Rosa*, Cristiana F. Pires*, Ilia Kurochkin, Alexandra G. Ferreira, Andreia M. Gomes, Luís G. Palma, Kritika Shaiv, Laura Solanas, Cláudia Azenha, Dmitri Papatsenko, Oliver Schulz, Caetano Reis e Sousa and Carlos-Filipe Pereira, Direct reprogramming of fibroblasts into antigen-presenting dendritic cells. Science Immunology 3, eaau4292 (2018). DOI: 10.1126/sciimmunol.aau4292

Nicholas Don-Doncow, Lotte Vanherle, Yun Zhang & Anja Meissner. T-cell accumulation in the hypertensive brain: a role for sphingosine-1-phosphate-mediated chemotaxis. Int J Mol Sci. 2019 Jan 28;20(3). doi: 10.3390/ijms20030537.

Bölükbas DA, De Santis MM, Alsafadi HN, Doryab A, Wagner DE. The Preparation of Decellularized Mouse Lung Matrix Scaffolds for Analysis of Lung Regenerative Cell Potential. Methods Mol Biol. 2019;1940:275-295. doi: 10.1007/978-1-4939-9086-3_20.

Stegmayr, J., Zetterberg, F., Carlsson, M. C., Huang, X., Sharma, G., Kahl-Knutson, B., Schambye, H., Nilsson, U. J., Oredsson, S., and Leffler, H. (2019) Extracellular and intracellular small-molecule galectin-3 inhibitors. Sci. Rep. 9, 2186

Markstad H, Edsfeldt A, Yao Mattisson I, Bengtsson E, Singh P, Cavalera M, Asciutto G, Björkbacka H, Fredrikson, GN Dias N, Volkov P, Orho-Melander M, Nilsson J, Engström G, Gonçalves I. High Levels of Soluble Lectinlike Oxidized Low-Density Lipoprotein Receptor-1 Are Associated With Carotid Plaque Inflammation and Increased Risk of Ischemic Stroke. J Am Heart Assoc. 19;8(4):e009874, 2019.

Y Liu, Lu Feng, Jia Xu, Zhengmeng Yang, Tianyi Wu, Jiajun Zhang, Liu Shi, Dahai Zhu, Gang Li et al. MiR-378a suppresses tenogenic differentiation and tendon repair by targeting at TGF-β2. Stem Cell Res Ther. 2019 Mar 29;10(1):108.
Ramos M, Burdon Bechet N, Battistella R, Pavan C, Xavier ALR, Nedergaard M, Lundgaard I. Cisterna Magna Injection in Rats to Study Glymphatic Function. Methods Mol Biol. 2019;1938:97-104. doi: 10.1007/978-1-4939-9068-9_7.

Wigren M, Rattik S, Grönberg C, Tomas L, Yao Mattisson I, Söderberg I, Alm R, Sundius L, Ljungcrantz I, Björkbacka H, Fredrikson GN, Nilsson J. Lack of ability to present antigens on MHC class II molecules aggravates atherosclerosis in ApoE-/- mice. Circulation, 2019 (ePub ahead of print)

Gerckens, M., Alsafadi, H. N., Wagner, D. E., Lindner, M., Burgstaller, G., & Königshoff, M. (2019). Generation of Human 3D Lung Tissue Cultures (3D-LTCs) for Disease Modeling. Journal of visualized experiments: JoVE, (144).



Rattik S, Mantani P, Yao Mattisson I, Ljungcrantz I, Sundius L, Björkbacka H, Holmgren J, Nilsson J, Wigren M, Fredrikson GN. B cells treated with p210-CTB acquire a regulatory phenotype in vitro and reduce atherosclerosis in apolipoprotein E deficient mice.  Vascular Pharmacology, 111: 54-61. 2018.

Nielsen, M. I., Stegmayr, J., Grant, O. C., Yang, Z., Nilsson, U. J., Boos, I., Carlsson, M. C., Woods, R. J., Unverzagt, C., Leffler, H., and Wandall, H. H. (2018) Galectin binding to cells and glycoproteins with genetically modified glycosylation reveals galectin-glycan specificities in a natural context. J. Biol. Chem. 293, 20249-20262

Y Liu, Lu Feng, Hua Wang, Yujia Wang, et al. Identification of an Anti-Inflammation Protein, Annexin A1, in Tendon Derived Stem Cells (TDSCS) of Cystic Fibrosis Mice: A Comparative Proteomic Analysis. Proteomics Clin Appl. 2018 Nov;12(6): e1700162.

Pignataro A, Meli G, Pagano R, Fontebasso V, Battistella R, Conforto G, Ammassari-Teule M, Middei S. Activity-Induced Amyloid-β Oligomers Drive Compensatory Synaptic Rearrangements in Brain Circuits Controlling Memory of Presymptomatic Alzheimer's Disease Mice. Biol Psychiatry. 2018 Nov 2. pii:S0006-3223(18)31980-2. doi: 10.1016/j.biopsych.2018.10.018. [Epub ahead of print] PubMed PMID: 30528194.

J.J. Uriarte, F.E Uhl, S.E. Rolandsson Enes, R.A. Pouliot, D.J. Weiss, “Lung bioengineering: advances and challenges in lung decellularization and recellularization.” Curr Opin Organ Transplant. 2018 Dec;23(6):673-678. PMID: 30300330